Type 1 diabetes, or insulin-dependent disease, is an autoimmune disorder in which the body does not produce insulin, the hormone necessary for the body to metabolize sugar. Without insulin, sugar cannot move from blood into the cells, causing the blood sugar to rise above a safe level and leaving cells without the ability to function properly. Type 1 is also known as Juvenile Diabetes. It is a lifelong disease and has many complications.
Peter Buchwald, Ph.D.
Dr. Buchwald and his team are investigating the possibility of reversing new-onset diabetes by targeting Smad7, a novel therapeutic target that is negative feedback regulator of TGF-β signaling. Read More
Denise Faustman, M.D., Ph. D.
Dr. Faustman is leading the human clinical trial program at Massachusetts General Hospital testing Bacillus Calmette-Guérin (BCG), an inexpensive generic drug, as a treatment for advanced type 1 diabetes.Read More
Dr. David Piston
After completing detailed chemical assays on blood samples from animals, the results showed that IGF-1 increases to normal levels and glucagon decreases back to normal levels within a few weeks after the brown fat transplants. Read More
Dr. Alice Tomei
Dr. Tomei's research focuses on immunoengineering islets for transplantation without immunosuppression and in identifying novel mechanisms for developing therapeutics to counteract autoimmunity. Read More